Download Advances in Cancer Stem Cell Biology by Roberto Scatena (auth.), Roberto Scatena, Alvaro Mordente, PDF

By Roberto Scatena (auth.), Roberto Scatena, Alvaro Mordente, Bruno Giardina (eds.)

In contemporary years, melanoma stem cells were famous as vital part in carcinogenesis and so they appear to shape the root of many (if no longer all) tumor varieties. melanoma stem cells or "cancer phone like stem cells" were remoted from numerous cancers of alternative beginning (blood, breast, mind, pores and skin, head and neck, thyroid, cervix, lung, retina, colon, pancreas and so on). melanoma stem cells - infrequent cells with indefinite proliferative strength that force the formation and progress of tumours- appear to convey exciting relationships with physiological stem cells. particularly, those melanoma cells convey major similarities within the mechanisms that control self-renewal of standard stem cells. additionally, tumour cells could without delay come up from basic stem cells. extra, the mobile biology of melanoma stem cells convey loads of similarities with general stem cells.

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Genes Dev 14:1343–1352 Krivtsov AV, Twomey D, Feng Z et al (2006) Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature 442:324–331 Lapidot T, Sirard C, Vormoor J et al (1994) A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367:645–648 Lee SMK, Tole S, Grove E et al (2000) A local Wnt-3a signal is required for development of the mammalian hippocampus. Development 197:457–467 Li L, Neaves WB (2006) Normal stem cells and cancer stem cells: The niche matters.

Actually, many of these stem cell-related microRNAs exhibit a differential expression in cancer cells. Changes in the expression pattern of miRNAs affect stem cell fate and disruption of this mechanism may have a contribution in the development of cancer. The interaction of some miRNAs with other factors regulating stem cell biology is illustrated in Fig. 1. The manipulation of miRNAs has become an important platform for molecular studies of different pathological processes. In cancer, miRNAs are being explored as diagnostic markers of malign tumors, as well as therapeutic tools (Sarkar et al.

The absence of miR-16 expression due to a deletion in chromosome 13 is found in patients with chronic lymphocytic leukemia, indicating that the miR-16 has a tumor suppressor activity (Navarro and Lieberman 2010). Actually, many of these stem cell-related microRNAs exhibit a differential expression in cancer cells. Changes in the expression pattern of miRNAs affect stem cell fate and disruption of this mechanism may have a contribution in the development of cancer. The interaction of some miRNAs with other factors regulating stem cell biology is illustrated in Fig.

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