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By Nigel Palastanga, Roger Soames

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A lever may be considered to be a simple rigid bar, with no account taken of its shape or structure. Most long bones appear as rigid bars but although many bones, such as those of the skull, are far from the usual concept of a lever they can, nevertheless, still act in this way. The fulcrum is the point around which the lever rotates. That part of the lever between the fulcrum and point of application of the force is known as the force arm, and that between the fulcrum and the point of application of the load is known as the load arm.

Hair colour is due to pigment in the hair cells (melanin and a subtle red pigment), and to air within the shaft of the hair. The hair of the head has a life span of between 2 and 4 years, while that of the eyelashes is only 3–5 months. All hairs are intermittently shed and replaced. In the growing hair, the deepest part of the hair follicle expands to form a cap, known as the bulb of the hair, which almost completely surrounds some loose, vascular connective tissue, known as the papilla. The cells of the follicle around the papilla proliferate to form the various layers of the hair.

Connecting the edge of the paraxial mesoderm to the lateral plate mesoderm is a longitudinal tract, the intermediate mesoderm, from which arises the nephrogenic cord. Within the lateral plate mesoderm small, fluid-filled spaces appear which join together to form the intra-embryonic mesoderm, continuous across the midline (Fig. 26A). The intra-embryonic mesoderm forms the pericardial (heart), pleural (lung) and peritoneal (abdominal) cavities. During the fourth week following fertilization the trilaminar disc bulges further into the amniotic cavity.

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